Pathogens, Free Full-Text
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Mycobacterium tuberculosis (Mtb) is a deadly pathogen and causative agent of human tuberculosis, causing ~1.5 million deaths every year. The increasing drug resistance of this pathogen necessitates novel and improved treatment strategies. A crucial aspect of the host–pathogen interaction is bacterial nutrition. In this study, Artemisia annua and Artemisia afra dichloromethane extracts were tested for bactericidal activity against Mtb strain mc26230 under hypoxia and various infection-associated carbon sources (glycerol, glucose, and cholesterol). Both extracts showed significant bactericidal activity against Mtb, regardless of carbon source. Based on killing curves, A. afra showed the most consistent bactericidal activity against Mtb for all tested carbon sources, whereas A. annua showed the highest bactericidal activity in 7H9 minimal media with glycerol. Both extracts retained their bactericidal activity against Mtb under hypoxic conditions. Further investigations are required to determine the mechanism of action of these extracts and identify their active constituent compounds.
Positive Directions, Inc.
Pathogens, Free Full-Text, renato ruiz história
Pathogens, Free Full-Text, staphylococcus aureus
Pathogens, Free Full-Text, staphylococcus aureus
PDF) Population Biology of Multi-Host Pathogens
Commensal bacteria in the upper respiratory tract regulate susceptibility to infection - ScienceDirect
PDF) A framework for the study of zoonotic disease emergence and its drivers: Spillover of bat pathogens as a case study
Pathogens, Free Full-Text, renato ruiz história
Pathogens, Free Full-Text
PDF) SEROLOGICAL SURVEY FOR SELECTED PATHOGENS IN FREE-RANGING COUGARS (PUMA CONCOLOR) IN SÃO PAULO, BRAZIL
PDF) Metagenomic profiling for gut of indigenous poultry reared under free range system of management reveal prevalence of zoonotic pathogens in chicken, while predominating beneficial microbes in duck
